GENE-THERAPY UTILIZING DRUG-RESISTANCE GENES - A REVIEW

Authors
BANERJEE D ZHAO SC LI MX SCHWEITZER BI MINEISHI S BERTINO JR
Citation
D. Banerjee et al., GENE-THERAPY UTILIZING DRUG-RESISTANCE GENES - A REVIEW, Stem cells, 12(4), 1994, pp. 378-385
Citations number
55
Categorie Soggetti
Cytology & Histology","Biothechnology & Applied Migrobiology
Journal title
Stem cells → ACNP
ISSN journal
10665099
Volume
12
Issue
4
Year of publication
1994
Pages
378 - 385
Database
ISI
SICI code
1066-5099(1994)12:4<378:GUDG-A>2.0.ZU;2-#
Abstract
The generation of drug resistant bone marrow may facilitate the develo pment of aggressive chemotherapeutic regimens that might otherwise be lethal due to marrow toxicity. With the availability of technology tha t permits in vitro manipulation of human marrow and peripheral blood s tem cells, it is now possible to introduce genes that confer drug resi stance to these hematopoietic progenitors. Animal models and in vitro work with human progenitors using drug resistance genes are reviewed.