We investigate the dependence of large-angular-scale cosmic microwave
background anisotropies on various initial conditions, including both
adiabatic and isocurvature perturbations and the initial power-law ind
ex n, in a variety of low-OMEGA cosmological models. LAMBDA-dominated
flat models, inflationary open adiabatic models, with n(eff) < 1, and
open isocurvature models, with n(eff) congruent-to 2, are significantl
y constrained.