METHYLPREDNISOLONE HAS A PREVENTIVE EFFECT ON HETEROTOPIC BONE-FORMATION AND ON KNEE THICKENING AND STIFFENING FOLLOWING MANIPULATION OF IMMOBILIZED RABBIT LEGS

Authors
MICHELSSON JE JUNTUNEN S VALTAKARI T MIKKOLA J
Citation
Je. Michelsson et al., METHYLPREDNISOLONE HAS A PREVENTIVE EFFECT ON HETEROTOPIC BONE-FORMATION AND ON KNEE THICKENING AND STIFFENING FOLLOWING MANIPULATION OF IMMOBILIZED RABBIT LEGS, Clinical and experimental rheumatology, 12(4), 1994, pp. 409-413
Citations number
43
Categorie Soggetti
Rheumatology
Journal title
Clinical and experimental rheumatology → ACNP
ISSN journal
0392856X
Volume
12
Issue
4
Year of publication
1994
Pages
409 - 413
Database
ISI
SICI code
0392-856X(1994)12:4<409:MHAPEO>2.0.ZU;2-G
Abstract
The effect of methylprednisolone administered following manipulation o f the immobilized knee of 35 adult rabbits was investigated. In the le gs of 15 control rabbits which received no methylprednisolone, heterot opic cartilage and bone in the periarticular tissues and in the vastus intermedius muscle, and extensive knee stiffening and thickening regu larly developed. In the other rabbits, methylprednisolone showed a mar ked preventive effect on the development of all these pathological sig ns.