6-ISOXAZOLINYL AND ISOXAZOLIDINYL SUBSTITUTED QUINAZOLINONES AS ANGIOTENSIN-II RECEPTOR ANTAGONISTS

Authors
LEVIN JI CHAN PS COUPET J BAILEY TK VICE G THIBAULT L LAI F VENKATESAN AM COBUZZI A
Citation
Ji. Levin et al., 6-ISOXAZOLINYL AND ISOXAZOLIDINYL SUBSTITUTED QUINAZOLINONES AS ANGIOTENSIN-II RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 4(14), 1994, pp. 1703-1708
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
14
Year of publication
1994
Pages
1703 - 1708
Database
ISI
SICI code
0960-894X(1994)4:14<1703:6AISQA>2.0.ZU;2-3
Abstract
The synthesis and biological evaluation of a series of 4(3H)-quinazoli nones substituted at the 6-position with isoxazolines and isoxazolidin es is described. Of these, compound 25a was found to be an especially potent, orally active, non-competitive angiotensin II receptor antagon ist.