SYNTHESIS AND BIOLOGICAL EVALUATION OF THE POTENT ISOXAZOLIDINYL ANGIOTENSIN-II RECEPTOR ANTAGONIST CL332,877 AND ITS ENANTIOMERS

Authors
LEVIN JI CHAN PS COUPET J THIBAULT L VENKATESAN AM BAILEY TK VICE G COBUZZI A LAI F MELLISH N
Citation
Ji. Levin et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF THE POTENT ISOXAZOLIDINYL ANGIOTENSIN-II RECEPTOR ANTAGONIST CL332,877 AND ITS ENANTIOMERS, Bioorganic & medicinal chemistry letters, 4(14), 1994, pp. 1709-1714
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
14
Year of publication
1994
Pages
1709 - 1714
Database
ISI
SICI code
0960-894X(1994)4:14<1709:SABEOT>2.0.ZU;2-6
Abstract
An alternative synthesis of CL332,877, a potent isoxazolidinyl-quinazo linone angiotensin II receptor antagonist, is described. In addition, the enantiomers of CL332,877 were separated and evaluated both in vitr o and in vivo.