SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF 15-OXOPROSTAGLANDINS - CONTRIBUTION OF THE OMEGA-CHAIN ENONE GROUP TO CYTOTOXICITY

Authors
LOPP M LOPP A PAJU A LILLE U PEHK T
Citation
M. Lopp et al., SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF 15-OXOPROSTAGLANDINS - CONTRIBUTION OF THE OMEGA-CHAIN ENONE GROUP TO CYTOTOXICITY, Bioorganic & medicinal chemistry letters, 4(14), 1994, pp. 1739-1744
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
14
Year of publication
1994
Pages
1739 - 1744
Database
ISI
SICI code
0960-894X(1994)4:14<1739:SAAAO1>2.0.ZU;2-K
Abstract
15-Oxo metabolites of prostaglandins E2, F2alpha and new 15-oxo prosta glandin analogues 5 and 7 were found to reveal higher antiproliferativ e activity than the corresponding 15-hydroxy derivatives on human leuk emia K562 cells in vitro. The responsibility of the enone group in the omega-chain of a prostanoid molecule for this activity is suggested.