3-ACETOXY-2,2'-BI-1H-INDOL AS A NOVEL INHIBITOR OF ATP BINDING TO DNAA, THE PROTEIN INITIATING CHROMOSOMAL REPLICATION IN ESCHERICHIA-COLI

Authors
SASAKI S MIZUSHIMA T HASHIMOTO T MAEDA M SEKIMIZU K
Citation
S. Sasaki et al., 3-ACETOXY-2,2'-BI-1H-INDOL AS A NOVEL INHIBITOR OF ATP BINDING TO DNAA, THE PROTEIN INITIATING CHROMOSOMAL REPLICATION IN ESCHERICHIA-COLI, Bioorganic & medicinal chemistry letters, 4(14), 1994, pp. 1771-1774
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
14
Year of publication
1994
Pages
1771 - 1774
Database
ISI
SICI code
0960-894X(1994)4:14<1771:3AANIO>2.0.ZU;2-D
Abstract
3-Acetoxy-2,2'-bi-1H-indol which is derived from indigo was found to b e a novel and potent inhibitor of ATP binding (IC50=0.04mM) to DnaA pr otein, a key protein in the initiation of chromosomal DNA replication in Escherichia coli. Competitive experiments indicated the inhibition to be non-competitive with ATP.