IN-VITRO EFFECTS OF A RECOMBINANT TOXIN, MSCF-PE40, TARGETING C-KIT RECEPTORS ECTOPICALLY EXPRESSED IN SMALL-CELL LUNG CANCERS

Authors
NISHIDA K SETO M TAKAHASHI T OSHIMA Y ASANO S TOJO A UEDA R
Citation
K. Nishida et al., IN-VITRO EFFECTS OF A RECOMBINANT TOXIN, MSCF-PE40, TARGETING C-KIT RECEPTORS ECTOPICALLY EXPRESSED IN SMALL-CELL LUNG CANCERS, Cancer letters, 113(1-2), 1997, pp. 153-158
Citations number
18
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
113
Issue
1-2
Year of publication
1997
Pages
153 - 158
Database
ISI
SICI code
0304-3835(1997)113:1-2<153:IEOART>2.0.ZU;2-B
Abstract
Most small cell lung cancers (SCLCs) ectopically express high levels o f the c-kit receptor. We have examined if the receptor can serve as a target for a chimeric toxin, mSCF-PE40 composed of murine stem cell fa ctor (SCF) genetically fused to the N terminus of a modified form of P seudomonas exotoxin (PE) lacking its cell recognition domain. Selectiv e cytotoxicity was found for human c-kit receptor-negative cells. This agent thus warrants further evaluation for therapy of human CSLCs. (C ) 1997 Elsevier Science Ireland Ltd.