INFECTIVITY OF TITERED DOSES OF SIMIAN IMMUNODEFICIENCY VIRUS CLONE E11S INOCULATED INTRAVENOUSLY INTO RHESUS MACAQUES (MACACA-MULATTA)

Authors
BENVENISTE RE ROODMAN ST HILL RW KNOTT WB RIBAS JL LEWIS MG EDDY GA
Citation
Re. Benveniste et al., INFECTIVITY OF TITERED DOSES OF SIMIAN IMMUNODEFICIENCY VIRUS CLONE E11S INOCULATED INTRAVENOUSLY INTO RHESUS MACAQUES (MACACA-MULATTA), Journal of medical primatology, 23(2-3), 1994, pp. 83-88
Citations number
21
Categorie Soggetti
Zoology,"Veterinary Sciences
Journal title
Journal of medical primatology → ACNP
ISSN journal
00472565
Volume
23
Issue
2-3
Year of publication
1994
Pages
83 - 88
Database
ISI
SICI code
0047-2565(1994)23:2-3<83:IOTDOS>2.0.ZU;2-F
Abstract
The macaque infectious dose (MID) of a single-cell clone of simian imm unodeficiency virus isolated from a pig-tailed macaque (SIV/Mne clone E11S) was determined in rhesus macaques (Macaca mulatta). Twenty-one m acaques were inoculated with 10-fold dilutions of the virus stock (thr ee or four animals per dose). The virologic and clinical status of the se animals was monitored for 26 weeks. The 25% MID (MID25) occurred at a 10(5)-fold dilution of the viral stock.