EFFICACY OF INACTIVATED WHOLE HIV-2 VACCINES WITH VARIOUS ADJUVANTS IN CYNOMOLGUS MONKEYS

Twenty-one cynomolgus monkeys were immunized with whole inactivated HI V-2 preparations administered with various adjuvants (incomplete Freun d's adjuvant, Alum, Ribi, MDP, or Iscoms) and challenged with 10 or 10 0 MID50 of a homologous monkey-cell grown, cell-free HIV-2. Seven anim als were completely protected against infection, three showed reduced virus replication. The vaccines elicited neutralizing and ADCC antibod ies; the titers did not correlate with protection. Immunization with a whole inactivated vaccine can protect primates from intravenous chall enge with a monkey-cell grown cell-free human immunodeficiency virus t ype 2.