EARLY ACTIVATION OF PBMC AND APPEARANCE OF ANTIVIRAL CD8-INDUCED DISEASE IN RHESUS MACAQUES( CELLS INFLUENCE THE PROGNOSIS OF SIV)

Authors
JOAG SV ADAMS RJ FORESMAN L GALBREATH D ZINK MC PINSON DM MCCLURE H NARAYAN O
Citation
Sv. Joag et al., EARLY ACTIVATION OF PBMC AND APPEARANCE OF ANTIVIRAL CD8-INDUCED DISEASE IN RHESUS MACAQUES( CELLS INFLUENCE THE PROGNOSIS OF SIV), Journal of medical primatology, 23(2-3), 1994, pp. 108-116
Citations number
18
Categorie Soggetti
Zoology,"Veterinary Sciences
Journal title
Journal of medical primatology → ACNP
ISSN journal
00472565
Volume
23
Issue
2-3
Year of publication
1994
Pages
108 - 116
Database
ISI
SICI code
0047-2565(1994)23:2-3<108:EAOPAA>2.0.ZU;2-D
Abstract
We studied 15 macaques inoculated with SIV and identified three phases of infection. Phase 1 was characterized by activated lymphocytes in b lood and infected cells in the CSF. In phase 2, activated cells were n ot detected but virus was recovered from mitogen-stimulated PBMC, whil e in phase 3, virus was recovered from mitogen-stimulated PBMC only af ter depletion of CD8+ lymphocytes, indicating effective control of the virus in peripheral blood. Early development of phase 3 status correl ated with a longer period of clinical normalcy.