CELLULAR IMMUNE-RESPONSES IN RHESUS MACAQUES INFECTED RECTALLY WITH LOW-DOSE SIMIAN IMMUNODEFICIENCY VIRUS

Authors
SALVATO MS EMAU P MALKOVSKY M SCHULTZ KT JOHNSON E PAUZA CD
Citation
Ms. Salvato et al., CELLULAR IMMUNE-RESPONSES IN RHESUS MACAQUES INFECTED RECTALLY WITH LOW-DOSE SIMIAN IMMUNODEFICIENCY VIRUS, Journal of medical primatology, 23(2-3), 1994, pp. 125-130
Citations number
29
Categorie Soggetti
Zoology,"Veterinary Sciences
Journal title
Journal of medical primatology → ACNP
ISSN journal
00472565
Volume
23
Issue
2-3
Year of publication
1994
Pages
125 - 130
Database
ISI
SICI code
0047-2565(1994)23:2-3<125:CIIRMI>2.0.ZU;2-Q
Abstract
Monkeys infected rectally with low dose simian immunodeficiency virus (SIV) were resistant to high dose challenge with SIV. Peripheral blood mononuclear cells (PBMC) from two of four challenged monkeys were una ble to support SIV replication in vitro unless cultures were depleted of CD8+ lymphocytes. Monkeys that had survived high dose rectal infect ion with SIV also suppressed virus replication in cultured PBMC. PBMC from uninfected monkeys supported virus replication in both unfraction ated and CD8-depleted cultures. Virus-suppressive activity of PBMC may be an important correlate of protective immunity in AIDS.