ANTIVIRAL ACTIVITY OF PRIMATE GAMMA-DELTA T-LYMPHOCYTES ISOLATED BY MAGNETIC CELL SORTING

Authors
WALLACE M GAN YH PAUZA CD MALKOVSKY M
Citation
M. Wallace et al., ANTIVIRAL ACTIVITY OF PRIMATE GAMMA-DELTA T-LYMPHOCYTES ISOLATED BY MAGNETIC CELL SORTING, Journal of medical primatology, 23(2-3), 1994, pp. 131-135
Citations number
22
Categorie Soggetti
Zoology,"Veterinary Sciences
Journal title
Journal of medical primatology → ACNP
ISSN journal
00472565
Volume
23
Issue
2-3
Year of publication
1994
Pages
131 - 135
Database
ISI
SICI code
0047-2565(1994)23:2-3<131:AAOPGT>2.0.ZU;2-Q
Abstract
The exposure of human or rhesus monkey peripheral blood mononuclear ce lls (PBMCs) to interleukin 2 (IL-2) in vitro resulted in a selective o utgrowth of gammadelta lymphocytes. Using positive selection by monocl onal antibodies and magnetic beads, gammadelta T lymphocytes were isol ated from these cultures. Without priming by viral antigens, the purif ied gammadelta T lymphocytes lyse immunodeficiency virus-infected cell s substantially better than the uninfected counterparts.