A HIGHLY ENANTIOSELECTIVE SYNTHESIS OF (-)-ANTIRHINE BY CHEMOENZYMATIC APPROACH

Authors
DANIELI B LESMA G MAURO M PALMISANO G PASSARELLA D
Citation
B. Danieli et al., A HIGHLY ENANTIOSELECTIVE SYNTHESIS OF (-)-ANTIRHINE BY CHEMOENZYMATIC APPROACH, Tetrahedron, 50(29), 1994, pp. 8837-8852
Citations number
41
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
29
Year of publication
1994
Pages
8837 - 8852
Database
ISI
SICI code
0040-4020(1994)50:29<8837:AHESO(>2.0.ZU;2-G
Abstract
(-)-Antirhine 2 was synthesized in an efficient and stereocontrolled f ashion from the readily available (1R-2S)-cyclohexene dimethanol monoa cetate 6. A key step was the regio- and stereoselective Pictet Spengle r cyclization of the masked dialdehyde 12 to the indoloquinolizidinone 13.