MICRODIALYSIS STUDY OF ISCHEMIA-INDUCED HYDROXYL RADICALS IN THE CANINE HEART

Authors
TIMOSHIN AA TSKITISHVILI OV SEREBRYAKOVA LI KUZMIN AI MEDVEDEV OS RUUGE EK
Citation
Aa. Timoshin et al., MICRODIALYSIS STUDY OF ISCHEMIA-INDUCED HYDROXYL RADICALS IN THE CANINE HEART, Experientia, 50(7), 1994, pp. 677-679
Citations number
26
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Experientia → ACNP
ISSN journal
00144754
Volume
50
Issue
7
Year of publication
1994
Pages
677 - 679
Database
ISI
SICI code
0014-4754(1994)50:7<677:MSOIHR>2.0.ZU;2-Y
Abstract
A new experimental approach for spin-trapping of oxygen radicals in a selected region of the heart in situ is described. This approach is ba sed on microdialysis, and it permits the detection of oxygen radicals in conditions of local ischemia and restoration of normal blood flow. Increased hydroxyl radical generation in an ischemic area of canine my ocardium, as a result of 40 min local occlusion, has been studied.