A CONVERGENT SYNTHESIS NOVEL CONFORMATIONALLY RESTRICTED HIV-1 PROTEASE INHIBITORS

Authors
KIM BM GUARE JP HANIFIN CM ARFORDBICKERSTAFF DJ VACCA JP BALL RG
Citation
Bm. Kim et al., A CONVERGENT SYNTHESIS NOVEL CONFORMATIONALLY RESTRICTED HIV-1 PROTEASE INHIBITORS, Tetrahedron letters, 35(29), 1994, pp. 5153-5156
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
29
Year of publication
1994
Pages
5153 - 5156
Database
ISI
SICI code
0040-4039(1994)35:29<5153:ACSNCR>2.0.ZU;2-0
Abstract
Conformationally restricted HIV-1 protease inhibitors containing the t ransition state hydroxyl group in pyrrolidine or piperidine ring syste ms were synthesized stereoselectively utilizing the inherent stereoche mistry of an amino acid derivative. A convergent double reductive amin ation strategy was used to construct the heterocyclic rings.