In the post decade, one of the most intriguing subjects in understandi
ng the mechanism of malaria infection has been explanation of the role
of Kupffer cells. These liver cells, which play an important part in
the body's defense against infection, seemed to have on essential supp
ortive role in the homing of sporozoites. Do Kupffer cells favor the e
stablishment of primary malaria infection? Extensive research has reve
aled much, but still not everything we need to know about the sporozoi
te-Kupffer cell affair.