INTERFERENCE OF HIGH-DOSE METHOTREXATE IN THE METABOLISM OF VALPROATE

Authors
SCHRODER H OSTERGAARD JR
Citation
H. Schroder et Jr. Ostergaard, INTERFERENCE OF HIGH-DOSE METHOTREXATE IN THE METABOLISM OF VALPROATE, Pediatric hematology and oncology, 11(4), 1994, pp. 445-449
Citations number
10
Categorie Soggetti
Pediatrics,Oncology,Hematology
Journal title
Pediatric hematology and oncology → ACNP
ISSN journal
08880018
Volume
11
Issue
4
Year of publication
1994
Pages
445 - 449
Database
ISI
SICI code
0888-0018(1994)11:4<445:IOHMIT>2.0.ZU;2-C
Abstract
A case of tonic-clonic seizure was observed in a child with acute lymp hoblastic leukemia a few hours after a 24-hour infusion of high-dose m ethotrexate (MTX; 5 g/m2). Because of former epileptic symptoms, the c hild had been treated with valproic acid for several months. During th is and the following high-dose MTX infusion, an acute decline of the s erum valproate concentration to about 25% of the pre-MTX value was obs erved. The pathogenesis of the acute decline Of serum valproate concen tration is discussed.