EVIDENCE FOR A MULTIGENIC SYSTEM CONTROLLING METHYL-BETA-CARBOLINE-3-CARBOXYLATE (BETA-CCM)-INDUCED SEIZURES

beta-CCM is a beta-carboline known to have properties opposite to thos e of benzodiazepines, Our approach was to analyze, in mice, the geneti c mechanisms involved in beta-CCM-induced myoclonic seizures using rec ombinant congenic strains and F-1 hybrids issued from these strains. O ur aim was to define the extent of the multigenic character of P-CCM-i nduced myoclonic seizures, while also evaluating the distribution of t he strength of the genes implicated in this trait. The results show th at the control of reactivity to P-CCM is multigenic with notable epist atic involvement.