CEFETAMET PIVOXIL IN THE TREATMENT OF COMMUNITY-ACQUIRED PNEUMONIA INCHILDREN

The efficacy and safety of cefetamet pivoxil in the treatment of commu nity-acquired pneumonia in children were assessed in an open, randomis ed, comparative multicentre study in which 260 children (in- and outpa tients) with either bacterial pneumonia (n = 170) or bronchopneumonia (n = 90) were enrolled. Cefetamet pivoxil, an oral third generation ce phalosporin, was administered to 85 children at a dosage of 10 mg/kg t wice daily, the recommended therapeutic dosage, and to 94 children at a dosage of 20 mg/kg twice daily. Cefaclor was administered to 81 chil dren at a dosage of 10 mg/kg three times daily. The duration of treatm ent was 7 days. Assessments were performed on days 0, 3, 7 and 14 afte r initiation of treatment. Clinical signs and symptoms began to improv e soon after the start of treatment, and continued to improve in all 3 treatment groups. The therapeutic outcome was considered successful i n 80 of the 81 assessable patients receiving cefetamet pivoxil 10 mg/k g twice daily (98.8%), in 79 of the 81 assessable patients receiving c efetamet pivoxil 20 mg/kg twice daily (97.6%), and in 71 of the 75 ass essable patients receiving cefaclor 10 mg/kg three times daily (94.7%) . The differences in outcome between the 3 groups were not statistical ly significant. Adverse events were of gastrointestinal origin (mainly diarrhoea, nausea, and/or vomiting), and occurred with similar freque ncies in the groups treated with cefetamet pivoxil 10 mg/kg twice dail y and cefaclor 10 mg/kg three times daily. Cefetamet pivoxil administe red at the standard dosage of 10 mg/kg twice daily was effective and w ell tolerated in children with bacterial pneumonia or bronchopneumonia . The twice-daily cefetamet pivoxil dose schedule compares favourably with the well-established cefaclor 3-times-daily regimen and may resul t in improved compliance.