HUMORAL IMMUNE-RESPONSES OF SOLOMON ISLANDERS TO THE MEROZOITE SURFACE-ANTIGEN-2 OF PLASMODIUM-FALCIPARUM SHOW PRONOUNCED SKEWING TOWARDS ANTIBODIES OF THE IMMUNOGLOBULIN G3 SUBCLASS

Authors
RZEPCZYK CM HALE K WOODROFFE N BOBOGARE A CSURHES P ISHII A FERRANTE A
Citation
Cm. Rzepczyk et al., HUMORAL IMMUNE-RESPONSES OF SOLOMON ISLANDERS TO THE MEROZOITE SURFACE-ANTIGEN-2 OF PLASMODIUM-FALCIPARUM SHOW PRONOUNCED SKEWING TOWARDS ANTIBODIES OF THE IMMUNOGLOBULIN G3 SUBCLASS, Infection and immunity, 65(3), 1997, pp. 1098-1100
Citations number
24
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
3
Year of publication
1997
Pages
1098 - 1100
Database
ISI
SICI code
0019-9567(1997)65:3<1098:HIOSIT>2.0.ZU;2-9
Abstract
The immunoglobulin G (IgG) subclass distribution of antibodies to mero zoite surface antigen 2 of Plasmodium falciparum in Solomon Islanders showed marked skewing towards the IgG3 subclass. This was not observed with crude P. falciparum schizont antigen. IgG3 responses may be shor t-lived and require repeated restimulation for their maintenance. This may be provided by persistent infection (premunition) or new infectio ns.