A NOVEL MALARIA PROTEIN, PFS28, AND PFS25 ARE GENETICALLY LINKED AND SYNERGISTIC AS FALCIPARUM-MALARIA TRANSMISSION-BLOCKING VACCINES

Authors
DUFFY PE KASLOW DC
Citation
Pe. Duffy et Dc. Kaslow, A NOVEL MALARIA PROTEIN, PFS28, AND PFS25 ARE GENETICALLY LINKED AND SYNERGISTIC AS FALCIPARUM-MALARIA TRANSMISSION-BLOCKING VACCINES, Infection and immunity, 65(3), 1997, pp. 1109-1113
Citations number
14
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
3
Year of publication
1997
Pages
1109 - 1113
Database
ISI
SICI code
0019-9567(1997)65:3<1109:ANMPPA>2.0.ZU;2-D
Abstract
Antibodies to Pfs28 block Plasmodium falciparum transmission and when combined with antibodies to Pfs25 provide synergy in blocking transmis sion. Pfs28 and Pfs25 are immunogenic, have limited antigenic diversit y, and are structurally similar and genetically linked on chromosome 1 0. Pfs28 may prove a useful addition to Pfs25 in an effective transmis sion-blocking vaccine.