COMPLEX KARYOTYPIC MOSAICISM AS A RESULT OF NONDISJUNCTION AND SUBSEQUENT CENTROMERE FISSION

Authors
PRABHAKAR G SCHWARTZ S WATERS E PUNZALAN C COHEN MM
Citation
G. Prabhakar et al., COMPLEX KARYOTYPIC MOSAICISM AS A RESULT OF NONDISJUNCTION AND SUBSEQUENT CENTROMERE FISSION, Prenatal diagnosis, 14(7), 1994, pp. 595-598
Citations number
22
Categorie Soggetti
Obsetric & Gynecology
Journal title
Prenatal diagnosis → ACNP
ISSN journal
01973851
Volume
14
Issue
7
Year of publication
1994
Pages
595 - 598
Database
ISI
SICI code
0197-3851(1994)14:7<595:CKMAAR>2.0.ZU;2-H
Abstract
Karyotypic discrepancy among four different cell types is described in tissues derived from a pregnancy terminated because of chromosomal an omalies. Chorionic villus cells demonstrated 46,XX (direct preparation ) and 46,XX/47,XX, + mar1 (cultured cells) karyotypes, while fetal ski n fibroblasts had a karyotype of 47,XX, + 18 and the placenta showed a triple mosaicism of 47,XX, + 18/47,XX, + mar1/48,XX, + 18, + mar2. Th e origin of this complex chromosomal distribution and its significance are discussed in comparison with findings in similar cases.