ANTICANCER EFFECTS OF ADRIAMYCIN-LOADED HYDROXYAPATITE IMPLANTS DETERMINED IN A SWARM RAT CHONDROSARCOMA MODEL

Authors
YAMAMURA K IWATA H OSADA T YOTSUYANAGI T NABESHIMA T
Citation
K. Yamamura et al., ANTICANCER EFFECTS OF ADRIAMYCIN-LOADED HYDROXYAPATITE IMPLANTS DETERMINED IN A SWARM RAT CHONDROSARCOMA MODEL, Japanese Journal of Pharmacology, 65(3), 1994, pp. 289-291
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Japanese Journal of Pharmacology → ACNP
ISSN journal
00215198
Volume
65
Issue
3
Year of publication
1994
Pages
289 - 291
Database
ISI
SICI code
0021-5198(1994)65:3<289:AEOAHI>2.0.ZU;2-I
Abstract
We investigated the antitumor effects of adriamycin (ADR)-loaded hydro xyapatite (HAP) beads in a Swarm rat chondrosarcoma model. When one AD R-loaded HAP bead (ADR: 0.8 mg/bead) was implanted into the central po rtion of a rat bearing tumor, the ADR-loaded HAP beads showed good the rapeutic effects, increasing the life span (ILS) by 90%. Significantly , leukopenia and diarrhea were not observed. These results suggest tha t HAP delivery offers an interesting and a potentially effective metho d.