THE IMMUNOPATHOGENESIS AND REGULATION OF T-CELL-MEDIATED DEMYELINATING DISEASES

Authors
MILLER SD KARPUS WJ
Citation
Sd. Miller et Wj. Karpus, THE IMMUNOPATHOGENESIS AND REGULATION OF T-CELL-MEDIATED DEMYELINATING DISEASES, Immunology today, 15(8), 1994, pp. 356-361
Citations number
48
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
15
Issue
8
Year of publication
1994
Pages
356 - 361
Database
ISI
SICI code
0167-5699(1994)15:8<356:TIAROT>2.0.ZU;2-B
Abstract
A variety of experimental approaches are currently being evaluated for controlling CD4(+) T helper 1 (Th1)-mediated autoimmune pathology. He re, Stephen Miller and william Karpus compare and contrast the efficac ies of various antigen-specific regulatory strategies. Particular emph asis is placed on the mechanisms of peripheral immune tolerance and ho w this may be used in the treatment and analysis of the pathologic T-c ell repertoire in autoimmune and virus-induced demyelinating diseases.