SYNTHESIS OF TERFENADINE CARBOXYLATE

Authors
PATEL S WAYKOLE L REPIC O CHEN KM
Citation
S. Patel et al., SYNTHESIS OF TERFENADINE CARBOXYLATE, Synthetic communications, 26(24), 1996, pp. 4699-4710
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
26
Issue
24
Year of publication
1996
Pages
4699 - 4710
Database
ISI
SICI code
0039-7911(1996)26:24<4699:SOTC>2.0.ZU;2-W
Abstract
A synthesis of terfenadine carboxylate, 1, a metabolite of terfenadine 2, is described. In the key step, the sodium salt of 2-(4-bromophenyl )-2-methylpropionic acid, 7, was lithiated via a metal-halogen exchang e using t-BuLi and subsequently condensed with ydroxydiphenylmethyl-pi peridin-1-yl]butyraldehyde, 5, to afford terfenadine carboxylate, 1.