TERBINAFINE-ASSOCIATED HEPATIC-INJURY

We describe two cases of terbinafine-associated hepatic injury, in whi ch a mixed cholestatic-hepatocellular type of hepa titis was present. In both cases extrahepatic cholestasis and viral hepatitis were exclud ed and involvement of other drugs was unlikely. In the first patient a ll abnormalities have disappeared, but in the second patient alkaline phosphatase, aminotransferase and gamma-glutamyl transferase levels ha ve remained elevated (follow up 3 months after cessation of treatment with terbinafine). Most likely, the terbinafine-associated hepatic inj ury in these patients was caused by an idiosyncratic rather than a dir ect hepatotoxic reaction. (C) Journal of Hepatology.