Aa. Elamin et al., THE EFFECT OF PRECOMPACTION PROCESSING AND STORAGE-CONDITIONS ON POWDER AND COMPACTION PROPERTIES OF SOME CRYSTALLINE MATERIALS, International journal of pharmaceutics, 108(3), 1994, pp. 213-224
The effect of humidity during the pre-compaction storage of milled act
ivated materials on the powder and compact properties was studied. Tes
t materials were sodium chloride, sucrose, dicalcium hydrogen phosphat
e (CHP) and acetylsalicylic acid (ASA). Storage of the milled powders
at 0% RH before compaction affected neither the powder characteristics
nor the tablet strength of the materials. Storage at high RH before c
ompaction affected the powder and tablet surface areas as well as redu
cing the tablet strength for sodium chloride. Crystallisation of the s
olid materials' activated surfaces occurred before compaction, i.e., a
deactivation of the milled material, mediated by the presence of wate
r vapour at the particle surfaces. For sucrose, a reduction in powder
surface area on pre-compaction storage at high RH did not lead to chan
ges in tablet strength. This was attributed to its fragmenting behavio
ur during compaction creating new bonding surfaces. Storage of sodium
chloride and sucrose compacts increased the tablet strength except at
0% RH, suggesting the existence of a lower critical RH, below which th
e compacts appeared to be physically stable. The pre-compaction powder
storage at high RH, reduced the post-compaction strength increase for
sodium chloride compacts. ASA and CHP being less water soluble were n
ot affected by RH on pre-compaction storage of the milled powders.