CHANGES OF CHOLINESTERASES IN THE BLOOD AND SOME TISSUES FOLLOWING ADMINISTRATION OF TACRIN AND ITS 2 DERIVATIVES TO RATS

Authors
BAJGAR J FUSEK J SKOPEC F
Citation
J. Bajgar et al., CHANGES OF CHOLINESTERASES IN THE BLOOD AND SOME TISSUES FOLLOWING ADMINISTRATION OF TACRIN AND ITS 2 DERIVATIVES TO RATS, Neurochemistry international, 24(6), 1994, pp. 555-558
Citations number
26
Categorie Soggetti
Biology,Neurosciences
Journal title
Neurochemistry international → ACNP
ISSN journal
01970186
Volume
24
Issue
6
Year of publication
1994
Pages
555 - 558
Database
ISI
SICI code
0197-0186(1994)24:6<555:COCITB>2.0.ZU;2-W
Abstract
Tacrin, its 7-methoxy-(MEOTA) and 7-hydroxy-(HYOTA) derivatives were i .m. administered to rats in a dose of 1.2 x LD(50) and acetylcholinesl erase (blood, hippocampus, Frontal cortex, basal ganglia, septum and d iaphragm) or butyrylcholinesterase (liver) activities were detected. T he inhibitory effect of the examined substances in vivo decreased in t he following order: tacrin HYOTA > MEOTA. The marked inhibition of the enzymes studied following administration of all three compounds in th e frontal cortex could suggest importance of this structure for action of these drugs.