THE DISTRIBUTION OF BIRTH WEIGHTS IN GAMBIAN WOMEN WHO RECEIVED MALARIA CHEMOPROPHYLAXIS DURING THEIR FIRST PREGNANCY AND IN CONTROL WOMEN

The distribution of birth weights among the infants of 172 Gambian pri migravidae who had received chemoprophylaxis with Maloprim(R) (pyrimet hamine+dapsone) during pregnancy was compared with that of the infants of 149 primigravidae who had received placebo. Administration of chem oprophylaxis led to a reduction in the prevalence of low birth weight babies and to an increase in the median birth weight. However, these c hanges were not accompanied by a comparable increase in the prevalence of high birth weight babies. The perinatal mortality rate was lower, although not significantly so, among the babies of women who had recei ved chemoprophylaxis. Thus, no evidence was found to support the view that administration of chemoprophylaxis might increase the risks of de livery by causing cephalo/pelvic disproportion.