G. Rodriguezmanzo et A. Fernandezguasti, REVERSAL OF SEXUAL EXHAUSTION BY SEROTONERGIC AND NORADRENERGIC AGENTS, Behavioural brain research, 62(2), 1994, pp. 127-134
The possible participation of the serotonergic and the noradrenergic s
ystems in the control of the inhibitory state present during sexual sa
tiation was studied from a pharmacological perspective. It was found t
hat the 5-HT1A agonist 8-OH-DPAT and the alpha(2) adrenoceptor antagon
ist, yohimbine were effective in reversing the sexual inhibition resul
ting from sexual exhaustion. These findings show that the inhibition p
resent during satiation is reversible and suggest that central mechani
sms underlie it. The serotonergic as well as the noradrenergic systems
, probably through their 5-HT1A and alpha(2) receptors, respectively,
play a role in the establishment of this phenomenon. Additionally, the
main features of the development of sexual exhaustion were reviewed.
It was found that sexual exhaustion has two different expressions: a m
ajor proportion of the exhausted rats does not copulate and a third pa
rt of this population is able to execute one ejaculatory series from w
hich they do not recover. The data are discussed in terms of the motiv
ational and consummatory components of male sexual behaviour.