SYNTHESIS AND ACTION ON THE CENTRAL-NERVOUS-SYSTEM OF SOME N-2-SUBSTITUTED CINNOLINE DERIVATIVES

Authors
STANCZAK A KWAPISZEWSKI W SZADOWSKA A PAKULSKA W
Citation
A. Stanczak et al., SYNTHESIS AND ACTION ON THE CENTRAL-NERVOUS-SYSTEM OF SOME N-2-SUBSTITUTED CINNOLINE DERIVATIVES, Die Pharmazie, 49(6), 1994, pp. 406-412
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
49
Issue
6
Year of publication
1994
Pages
406 - 412
Database
ISI
SICI code
0031-7144(1994)49:6<406:SAAOTC>2.0.ZU;2-Q
Abstract
Alkylation of 4-hydroxycinnolines using ethyl bromoacetate resulted in N-2-substituted acetic acids. These acids were converted to esters an d amides. Some of the obtained acids were reduced with zinc dust to gi ve 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the co mpounds were tested for their effect on central nervous system.