STABILITY AND COMPATIBILITY STUDIES OF CEFALORIDINE, CEFUROXIME AND CEFTAZIDIME WITH PVC INFUSION BAGS

A rapid isocratic technique was developed for the analysis of three ce phalosporins: cefaloridine, cefuroxime and ceftazidime in parenteral s olutions using high-performance liquid chromatography (HPLC) with UV d etection and C18 column. The availability and compatibility of drugs f rom solutions infused via plastic infusion bags through plastic admini stration sets have been examined. No significant drugs loss was observ ed during the simulated infusions (n = 4) for 1 h using PVC infusion b ags and administration sets. No significant difference was found betwe en infusion solutions (5% glucose or 0.9% NaCl). The stability of drug s was also studied in solution in PVC bags after storage at room tempe rature and at +4 degrees C without protection from light. The results show the stability of drugs during 24 h at room temperature and 7 d st orage at +4 degrees C to be satisfactory, irrespective of the infusion solution (5% glucose or 0.9% NaCl).