A PRELIMINARY EVALUATION OF THE PERFORMANCE OF THE MUTA(TM) MOUSE (LACZ) AND BIG BLUE(TM) (LACI) TRANSGENIC MOUSE MUTATION ASSAYS

All of the published mutagenicity data generated using the Muta(TM) Mo use (lacZ) and the Big Blue(TM) (lacl) transgenic mouse mutation assay s have been re-presented in a standard format. To date, 26 chemicals h ave been evaluated in one or other of the assays, and eight tissues ha ve been sampled. The present analysis should expedite the further vali dation of these assays. In particular, it is suggested that data on th e present 26 chemicals should be consolidated rather than the generati on of partial data sets on additional chemicals.