Hp. Bozigian et al., ONDANSETRON ABSORPTION IN ADULTS - EFFECT OF DOSAGE FORM, FOOD, AND ANTACIDS, Journal of pharmaceutical sciences, 83(7), 1994, pp. 1011-1013
Ondansetron is a competitive serotonin 5-HT3 receptor blocker that has
proved useful in the prevention of emesis due to cisplatin and other
cancer chemotherapeutic agents. In a randomized, open-label, crossover
study in 24 healthy male subjects, the relative bioavailability of a
single 8-mg tablet was compared with that of an 8-mg solution using th
e two one-sided t-tests. The tablet and solution formulations were bio
equivalent, as confirmed by similarities in mean C-max (26.3 vs 27.7 n
g/ml), T-max (1.79 vs 1.70 h), and AUC (166.0 vs 167.3 ng.h/ml) values
. In another randomized, open-label, crossover study In 12 healthy mal
e subjects, the bioavailability of an 8-mg ondansetron tablet administ
ered 5 min after a standard meal was slightly but significantly greate
r than in fasted subjects, as indicated by comparative mean AUC values
[201.4 ng.h/mL (fed) vs 172.5 ng.h/mL (fasted)]. Coadministration of
a magnesium hydroxide/ aluminum hydroxide antacid did not affect the b
ioavailability of the ondansetron tablet.