A. Martini et al., USE OF DEHYDRATED BETA-CYCLODEXTRIN AS PHARMACEUTICAL EXCIPIENT, Drug development and industrial pharmacy, 20(15), 1994, pp. 2381-2393
Cyclodextrins, and expecially beta ones, are widely used in the pharma
ceutical field for their ability of improving the solubility and the s
tability of drugs by complex formation at the solid state. Such phenom
enon occurs only when cyclodextrin has a certain water content, being
the removal of water from internal cavity essential for the interactio
n between the drug and the excipient. Anyway, the dehydration of beta
cyclodextrin leads to a product with peculiar properties, which is rep
orted to be not able to form inclusion complex at the solid state, but
is very effective in increasing the rate of complex formation in solu
tion with a consequent strong influence on dissolution performances of
drugs. This approach is extremely interesting for obtaining fast diss
olving tablets of drugs that are able for their own characteristics, t
o form stable solid inclusion complexes only in solution, but not at t
he solid state. The formulation process is extremely simple and of low
cost involving only the physical mixing of the drug with the excipien
ts before tableting or other pharmaceutical processes.