ANTISENSE OLIGONUCLEOTIDES WITH 3'-TERMIN AL AND 5'-TERMINAL 1-(BETA-D-2'-DEOXY-THREO-PENTAFURANOSYL)THYMIN

Authors
KRYNETSKAYA NF CHEBOTAR OA IBRAHIM HKH ROMANOVA EA TASHLITSKY VN ORETSKAYA TS SOKOLOVA NI SHABAROVA ZA
Citation
Nf. Krynetskaya et al., ANTISENSE OLIGONUCLEOTIDES WITH 3'-TERMIN AL AND 5'-TERMINAL 1-(BETA-D-2'-DEOXY-THREO-PENTAFURANOSYL)THYMIN, Bioorganiceskaa himia, 20(6), 1994, pp. 669-675
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
20
Issue
6
Year of publication
1994
Pages
669 - 675
Database
ISI
SICI code
0132-3423(1994)20:6<669:AOW3AA>2.0.ZU;2-X
Abstract
Oligonucleotides with 3'- and 5'-terminal 1-(beta-D-2'-deoxy-threopent afuranosyl)thymin residues (inversion at C3'-atom) were obtained by th e automatic phosphoramidite synthesis. The modifications protect oligo nucleotides from the nuclease degradation and do not affect the stabil lity of nucleic acid duplexes.