INDONESIAN MEDICINAL-PLANTS .8. CHEMICAL STRUCTURES OF 3 NEW TRITERPENOIDS, BRUCEAJAVANIN-A, DIHYDROBRUCEAJAVANIN-A, AND BRUCEAJAVANIN-B, AND A NEW ALKALOIDAL GLYCOSIDE, BRUCEACANTHINOSIDE, FROM THE STEMS OF BRUCEA-JAVANICA (SIMAROUBACEAE)

Three new apotirucallane-type triterpenoids named bruceajavanin A (1) dihydrobruceajavanin A (2), and bruceajavanin B (3), and a novel beta- carboline alkaloidal glycoside named bruceacanthinoside (4) were isola ted from the stems of Brucea javanica (Simaroubaceae), a traditional m edicine used to treat malaria in the Bengkulu area, Sumatra, Indonesia . Their chemical structures have been elucidated on the bases of their chemical and physicochemical properties. Bruceajavanin A (1), dihydro bruceajavanin A (2) and bruceacanthinoside (4) were shown to inhibit g rowth of the cultured malarial parasite Plasmodium falciparum K1 of a chloroquine-resistant strain.