PRACTICAL TOTAL SYNTHESES OF (R)-(-14-HYDROXY-4,14-RETRO-RETINOL AND (S)-(-)-14-HYDROXY-4,14-RETRO-RETINOL())

Authors
NAGAI M YOSHIMURA H HIBI S KIKUCHI K ABE S ASADA M YAMAUCHI T HIDA T HIGASHI S HISHINUMA I YAMANAKA T
Citation
M. Nagai et al., PRACTICAL TOTAL SYNTHESES OF (R)-(-14-HYDROXY-4,14-RETRO-RETINOL AND (S)-(-)-14-HYDROXY-4,14-RETRO-RETINOL()), Chemical and Pharmaceutical Bulletin, 42(7), 1994, pp. 1545-1547
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
7
Year of publication
1994
Pages
1545 - 1547
Database
ISI
SICI code
0009-2363(1994)42:7<1545:PTSO(A>2.0.ZU;2-L
Abstract
Practical and facile total syntheses of the remarkably unstable (R)-()-14-hydroxy-4, 14-retroretinol [(R)-14HRR] 1 and of its enantiomer 2 have been achieved via an acid-catalyzed dehydration reaction of the r espective tetraeneol intermediates 10 and its enantiomer obtained from (R)-(+)-1,2-O-isopropylidene-butane-1, 2,3-triol 3.