PROGNOSTIC FACTORS IN BLADDER-CANCER - A PATHOLOGICAL, IMMUNOHISTOCHEMICAL, AND DNA FLOW-CYTOMETRIC STUDY

Pathologic grade and stage, immunohistochemical analysis of eight cell and tumor markers, and DNA ploidy were studied in 36 cases of bladder cancer to determine the features of value in assessment of patients' survival. Tumors of high grade and advanced stage correlated with DNA aneuploidy, whereas low grade and early stage correlated with DNA dipl oidy when simultaneously evaluated with survival. In addition, blood g roup isoantigen A correlated with DNA ploidy in deceased patients, whe reas blood group isoantigen H and oncogene-related protein p21 correla tedwell with DNA ploidy in surviving patients. Despite the relatively small number of cases studied, these results suggest that pathologic g rade and stage and immunohistochemical analysis of blood group isoanti gens A and H and oncogene-related protein p21 hold additional value in the prediction of bladder cancer survival when evaluated simultaneous ly with DNA ploidy.-