M. Kasra et Md. Grynpas, EFFECT OF LONG-TERM OVARIECTOMY ON BONE MECHANICAL-PROPERTIES IN YOUNG FEMALE CYNOMOLGUS MONKEYS, Bone, 15(5), 1994, pp. 557-561
Feral adult female cynomolgus monkeys were divided into two groups: no
rmal controls and ovariectomized. Tibiae and trabecular bones from the
femoral head, from each group, were tested using a materials testing
machine. The bending stiffness of the tibiae was measured by nondestru
ctive three-point bending tests and their maximum torque capacity by d
estructive torsion tests. The compressive strength of the trabecular b
ones was measured by compression tests. Ovariectomy caused significant
decreases in elastic modulus of the tibiae (p < 0.008), measured by t
hree-point bending tests, and in shear modulus (p < 0.015), failure sh
ear stress (p < 0.01), and failure torque (p < 0.001) of the tibiae, m
easured by torsion tests. It caused a significant decrease in cortical
bone density (p < 0.005), but no significant changes in tibial cross-
sectional area and in cortical shaft external and internal diameters.
The differences in elastic modulus, maximum compressive strength, and
density of femoral trabecular bone samples between the two groups were
not significant.