INSECTICIDAL PROPERTIES OF MONOTERPENOID DERIVATIVES TO THE HOUSE-FLY(DIPTERA, MUSCIDAE) AND RED FLOUR BEETLE (COLEOPTERA, TENEBRIONIDAE)

Monoterpenoid derivatives were synthesized and their insecticidal acti vities were evaluated against red flour beetles, Tribolium castaneum ( Herbst), in fumigant bioassays and against house flies Musca domestica (L.) in topical, fumigant, and ovicidal bioassays. Acetate derivative s and haloacetate derivatives were compared with each other, and with the parent monoterpenoid to determine structure-activity relationships . Acetate derivatives were more active than the propionate derivatives of cyclic monoterpenoids in the topical, fumigant, and ovicidal bioas says. Pivalates were topically more insecticidal than acetates to adul t house flies, while the acetates had the greater ovicidal activity. A cetates and pivalates were more effective than haloacetates in the top ical, red flour beetle fumigation and ovicidal bioassays. Fluoroacetat es of cyclic monoterpenoids were the most effective house fly fumigant s, followed by acetates, and trichloroacetates. Several derivatives we re produced that displayed enhanced activity relative to the parent al cohols or phenols.