L. John et al., RATE OF PROGRESSION OF ALBUMINURIA IN TYPE-II DIABETES - 5-YEAR PROSPECTIVE-STUDY FROM SOUTH-INDIA, Diabetes care, 17(8), 1994, pp. 888-890
Citations number
6
Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
OBJECTIVE - To evaluate the potential risk factors for the progression
of albuminuria in type II diabetes. RESEARCH DESIGN AND METHODS - A c
ohort of 481 type II diabetic patients were followed prospectively for
5 years. Blood glucose (BG) and blood pressure (BP) were checked at 2
monthly intervals, and urinary albumin excretion (UAE) was checked at
yearly intervals. Progression of albuminuria was recognized by the de
velopment of microalbuminuria and macroalbuminuria and a significant i
ncrease in albuminuria within the mitroalbuminuric range. RESULTS - UA
E was normal in 349 patients, 93 patients were microalbuminuric, and t
he rest (39) were macroalbuminuric. Sixty-two patients with normal UAE
developed microalbuminuria. Ten patients with normoalbuminuria and 23
with microalbuminuria developed macroalbuminuria during the 5-year ob
servation period with overall incidence of 46.9/1,000 person-years for
normoalbuminuria and 58.7/1,000 person-years for microalbuminuria. Ba
seline UAE was significantly higher in those patients who progressed c
ompared with those patients who did not (normoalbuminuria: 8.5 +/- 6 v
s. 5.3 +/- 4 mu g/min, P < 0.001; microalbuminuria: 68.5 +/- 57 vs. 47
.4 +/- 34 mu g/min, P < 0.01). Multiple regression analysis revealed i
nitial UAE and diabetes duration to be predictors of albuminuria progr
ession. CONCLUSIONS - Initial UAE is a strong predictor of albuminuria
progression in type II diabetic patients.