DO GROWTH-FACTORS STIMULATE ANGIOGENESIS - A COMPARISON OF PUTATIVE ANGIOGENESIS FACTORS

Authors
PHILLIPS GD STONE AM SCHULTZ JC JONES BD GOODKIN ML LISOWSKI MJ WHITEHEAD RA FIEGEL VD KNIGHTON DR
Citation
Gd. Phillips et al., DO GROWTH-FACTORS STIMULATE ANGIOGENESIS - A COMPARISON OF PUTATIVE ANGIOGENESIS FACTORS, Wounds, 9(1), 1997, pp. 1-14
Citations number
66
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Wounds → ACNP
ISSN journal
10447946
Volume
9
Issue
1
Year of publication
1997
Pages
1 - 14
Database
ISI
SICI code
1044-7946(1997)9:1<1:DGSA-A>2.0.ZU;2-9
Abstract
Acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF), transforming growth factor alpha (TGF-alpha), transforming gr owth factor beta (TGF-beta), epidermal growth factor (EGF), vascular e ndothelial growth factor (VEGF(165)), tumor necrosis factor alpha (TNF -alpha), and platelet-derived growth factor BE (PDGF-BB) were incorpor ated into slow release polymers and implanted in the rabbit cornea as an assay for angiogenesis activity. VEGF and low doses of PDGF-BB were direct angiogenesis factors, stimulating endothelial cells to form ca pillaries in the absence of inflammation. TGF-beta was an indirect ang iogenesis factor, eliciting angiogenesis through the recruitment of in flammatory cell mediators. TGF-alpha and EGF were ''bifunctional'' ang iogenesis factors. Both factors recruited inflammatory cells prior to angiogenesis, but when the inflammation was blocked, angiogenesis stil l proceeded, Acidic FGF, bFGF and TNF-alpha were non-angiogenic.