IRON CHELATES IN BIOLOGICAL-SYSTEMS - ITS RELEVANCE TO INDUCTION OF PATHOGENESIS OF TISSUE-DAMAGE AND CARCINOGENESIS

Authors
NISHIDA Y GOTO A AKAMATSU T OHBA S FUJITA T TOKII T OKADA S
Citation
Y. Nishida et al., IRON CHELATES IN BIOLOGICAL-SYSTEMS - ITS RELEVANCE TO INDUCTION OF PATHOGENESIS OF TISSUE-DAMAGE AND CARCINOGENESIS, Chemistry Letters, (3), 1994, pp. 641-644
Citations number
14
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
3
Year of publication
1994
Pages
641 - 644
Database
ISI
SICI code
0366-7022(1994):3<641:ICIB-I>2.0.ZU;2-X
Abstract
Iron-nta(nitrilotriacetate) solution induces severe nephrotoxicity and high accidence of renal carcinoma in rats and mice, however, the effe ct by an iron-pac(2-aminomethylpyridine-N,N-diacetate) solution is neg ligible. These facts were interpreted in terms of different reactivity of the two compounds toward hydrogen peroxide.