HELICOBACTER-PYLORI

Helicobacter pylori infection continues to generate considerable inter est in the medical and scientific community. There is now overwhelming evidence to confirm that H. pylori plays an etiologic role in the dev elopment of chronic active gastritis, peptic ulcer disease, and gastri c cancer. Tremendous progress continues to be made in identifying the pathogenic mechanisms by which chronic H. pylori infection promotes th e development of gastroduodenal disease. This review outlines the rece nt contribution to the literature and focuses on the epidemiology, dia gnosis, and therapy of H. pylori, an update on vaccine development, an d new insights into the pathogenic mechanisms resulting in the develop ment of gastroduodenal disease.