MITOMYCIN-C AS ADJUNCTIVE THERAPY WITH GLAUCOMA IMPLANT-SURGERY

Twenty-one eyes of 21 patients with refractory glaucoma underwent glau coma surgery involving placement of a modified Molteno implant and int raoperative application of mitomycin C. Sixteen eyes (76.2%) had an in traocular pressure (IOP) of 21 mm Hg or less after a mean follow up of 9.4 +/- 6.4 months; additional medication was needed in six eyes. Maj or complications included early flat anterior chamber (42.9%), implant plate erosion (9.5%), tube erosion (4.8%), late hypotony 4.8%), tube- corneal touch (4.8%), and phthisis bulbi after choroidal hemorrhage (4 .8%). Only one patient had a high IOP due to decreased filtration thro ugh the implant. These results suggest that glaucoma implant surgery w ith the adjunctive use of mitomycin C may be useful in eyes with refra ctory glaucoma.