ORAL PENTOXIFYLLINE IN THERAPY-RESISTANT IDIOPATHIC OAT SYNDROME

After previous treatment failure using tamoxifen either alone or in co mbination with kallikrein, 25 patients with idiopathic oligoasthenoter atozoospermia (OAT syndrome) were subjected to 3 months of treatment w ith pentoxifylline at a dosage of 1200 mg/day. The only statistically significant (p < .008) improvement detected in the post-therapeutic sp ermiograms was an increase of normal forms. All other ejaculate parame ters (density, motility, swelling test, penetration test) remained unc hanged, and there was only one post-therapeutic pregnancy. It would ap pear the pentoxifylline after failure of established treatment modalit ies is not a therapy of choice in idiopathic OAT syndrome.