MAXIMUM-LIKELIHOOD GENETIC SEQUENCE RECONSTRUCTION FROM OLIGO CONTENT

One promising technique for determining long genetic sequences is sequ encing by oligonucleotide content. This technique involves probing a s egment of the unknown multimillion ''character'' genetic sequence for the presence or absence of known short subsequences. The information o btained from such hybridization experiments may be represented in netw ork form. Network optimization methods may then be applied to identify the most likely forms of the unknown target sequence. (C) 1994 John W iley & Sons, Inc.