Jh. Check et al., THE EFFECT OF SERA ANTISPERM ANTIBODIES IN THE FEMALE PARTNER ON IN-VIVO AND IN-VITRO PREGNANCY AND SPONTANEOUS-ABORTION RATES, American journal of reproductive immunology [1989], 33(1), 1995, pp. 131-133
PROBLEM: To determine the incidence of antisperm antibodies (ASA) in f
emale sera from infertile couples or those suffering from recurrent ab
ortions. Also to determine if the pregnancy and/or abortion rates are
any higher in those positive versus those negative for ASA. METHOD: Al
l registered patients had sera drawn and ASA measured by indirect immu
nobead test on initial study. Pregnancy and abortion rates were determ
ined for patients undergoing in vivo or in vitro therapy. RESULTS: The
re was a low incidence of ASA in patients having in vivo or in vitro t
reatment. There was no decrease in pregnancy rates (PRs) or increase i
n spontaneous abortions (SAB) in those positive for ASA. CONCLUSION: A
ntisperm antibodies in female sera do not seem to be etiologic in caus
ing infertility or SAB. Future studies might consider changing the ant
igen source from donor sperm to husband's sperm.